Premium
IC–P–020: MRI biomarkers as predictors of mortality in dementia
Author(s) -
Henneman Wouter J.P.,
Sluimer Jasper D.,
Cordonnier Charlotte,
Baak Merel M.E.,
Scheltens Philip,
Barkhof Frederik,
Flier Wiesje M.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.2225
Subject(s) - dementia , medicine , atrophy , population , magnetic resonance imaging , temporal lobe , rating scale , pediatrics , disease , pathology , psychology , psychiatry , radiology , developmental psychology , environmental health , epilepsy
surfaces were parametrized, flattened and warped so that data from corresponding gyri could be explicitly matched before averaging across subjects. Segmented GM was mapped onto the corresponding parametric hemispheric model in exact spatial correspondence. An average group 3D gray matter density map was created for each group. Statistical maps of the linkage between structural differences and clinical diagnosis were created. Results: SD diagnosis correlated with GM atrophy in the following regions: left posterior superior (r 0.3) and inferior (r 0.4) temporal gyri, left temporooccipital (r 0.4), left fusiform (r 0.4) and the precentral and postcentral gyri bilaterally(r 0.4). FTD diagnosis correlated with GM atrophy of bilateral medial and lateral frontal association (r 0.3-0.4) and the left orbitofrontal (r 0.4) cortices, as well as the right middle and inferior temporal gyri (r 0.3). Conclusions: Using innovative 3D cortical mapping techniques our preliminary work shows a predominantly leftsided and posterior GM atrophy pattern in SD and more right-sided and frontal GM atrophy pattern in FTD.