O3–04–03: Physical activity at midlife and the risk of dementia and Alzheimer's disease | Zendy

Rovio Suvi | Zendy; Kåreholt Ingemar | Zendy; Viitanen Matti | Zendy; Winblad Bengt | Zendy; Tuomilehto Jaakko | Zendy; Soininen Hilkka | Zendy; Nissinen Aulikki | Zendy; Kivipelto Miia | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

O3–04–03: Physical activity at midlife and the risk of dementia and Alzheimer's disease

Author(s) -

Rovio Suvi,

Kåreholt Ingemar,

Viitanen Matti,

Winblad Bengt,

Tuomilehto Jaakko,

Soininen Hilkka,

Nissinen Aulikki,

Kivipelto Miia

Publication year - 2006

Publication title -

alzheimer's and dementia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.713

H-Index - 118

eISSN - 1552-5279

pISSN - 1552-5260

DOI - 10.1016/j.jalz.2006.05.216

Subject(s) - dementia , gerontology , physical activity , medicine , disease , apolipoprotein e , epidemiology , cohort , vascular dementia , population , alzheimer's disease , cohort study , psychology , physical therapy , environmental health

found them to be reduced in PS1(n-/-) mice while increased in PS1[A246E] mice. These biochemical findings correlate with decreased and increased levels of nuclear c-Fos in PS1(n-/-) mice and PS1[A246E] mice, respectively. Finally, while PS1[A246E] and PS1(n-/-) mice both performed normally in object recognition and spatial navigation tasks, the PS1[A246E] mice displayed improved contextual fear conditioning, in contrast to a subtle impairment in PS1(n-/-) mice in this task. Conclusion: Our data demonstrate both preand postsynaptic roles for wild-type PS1 in synaptic plasticity, while mutant PS1[A246E] acts post-synaptically and opposite to PS1-deficiency.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research