Premium
O3–04–03: Physical activity at midlife and the risk of dementia and Alzheimer's disease
Author(s) -
Rovio Suvi,
Kåreholt Ingemar,
Viitanen Matti,
Winblad Bengt,
Tuomilehto Jaakko,
Soininen Hilkka,
Nissinen Aulikki,
Kivipelto Miia
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.216
Subject(s) - dementia , gerontology , physical activity , medicine , disease , apolipoprotein e , epidemiology , cohort , vascular dementia , population , alzheimer's disease , cohort study , psychology , physical therapy , environmental health
found them to be reduced in PS1(n-/-) mice while increased in PS1[A246E] mice. These biochemical findings correlate with decreased and increased levels of nuclear c-Fos in PS1(n-/-) mice and PS1[A246E] mice, respectively. Finally, while PS1[A246E] and PS1(n-/-) mice both performed normally in object recognition and spatial navigation tasks, the PS1[A246E] mice displayed improved contextual fear conditioning, in contrast to a subtle impairment in PS1(n-/-) mice in this task. Conclusion: Our data demonstrate both preand postsynaptic roles for wild-type PS1 in synaptic plasticity, while mutant PS1[A246E] acts post-synaptically and opposite to PS1-deficiency.