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P4–398: Acetylcholinesterase inhibitors in schizophrenic patients with cognitive deficit
Author(s) -
Ribeiz Salma R.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.2139
Subject(s) - acetylcholinesterase , cognitive deficit , cognition , basal forebrain , cholinergic , schizophrenia (object oriented programming) , disease , medicine , cognitive decline , acetylcholinesterase inhibitor , cholinergic neuron , donepezil , psychology , neuroscience , psychiatry , dementia , cognitive impairment , biology , enzyme , biochemistry
energy expenditure (calculated from the total load of exercise a month) together with accumulated urinary cortisol level were also measured. Results: During the two years of exercise intervention, 70% of the subjects participated and all showed significant improvement in their memory and physical functions, and decreased depression scores and urinary cortisol level. Improved memory skill was positively correlated with mean energy expenditure (individual) and participation rate (community-based), whereas negatively correlated with urinary cortisol level. Conclusions: The exercise intervention trial can be effective in improving the participation rate of subjects. An important future prospect is to implement interactive and enjoyable exercise interventions, e.g. a calisthenics program accompanied by singing, that possess practical and clinical benefits at improving overall physical fitness while abating stress and cognitive decline for elderly persons, including MCI cases.