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P4–360: Theta oscillations are phase locked after cholinesterase inhibitors in frontal area in Alzheimer's disease
Author(s) -
Yener Gorsev G.,
Güntekin Bahar A.,
Öniz Adile T.,
Başar Erol
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.2101
Subject(s) - psychology , cholinesterase , neuroscience , cholinergic , stimulation , oddball paradigm , electroencephalography , alzheimer's disease , medicine , event related potential , disease
Background: Theta oscillations are involved in mnemonic processes. Alzheimer’s disease (AD) is a common amnestic disorder. The current cholinesterase inhibitors may improve cognitive processes and affect the brain oscillations. Objective(s): To compare phase locking of theta event related oscillations in non-treated AD and treated AD and healthy elderly controls in frontal areas. Methods: Phase locking of theta (4-7Hz) event related oscillations of 22 mild probable AD patients (11 non-treated and 11 treated with cholinesterase inhibitors) and 20 healthy elderly controls were compared by using conventional visual oddball paradigm. Conclusions: At F3 location, theta responses of healthy subjects show stronger phase locking to stimulation than non-treated AD patients and the treated AD group has theta phase locking as strong as the control subjects. The F4 theta responses were not statistically significant between the groups. Our findings imply that the theta responses at F3 location are highly instable in comparison to F4 in non-treated mild AD patients and cholinergic agents may modulate event related theta oscillatory activities in the frontal regions.