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P4–293: Evidence for an age dependent rate limiting pool of CNS Aβ in PDAPP mouse altered by Aβ antibody administration
Author(s) -
Racke Margaret M.,
Bryan Matthew T.,
DeMattos Ronald B.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.2032
Subject(s) - antibody , genetically modified mouse , limiting , ratón , dosing , medicine , endocrinology , potency , immunology , transgene , biology , chemistry , in vitro , biochemistry , gene , mechanical engineering , engineering
eling of serial imaging data demonstrated that single exposure to anti-A antibody resulted in mild regression of CAA deposits (-0.49% vessel surface area per day versus 0.5% per day progression with control antibody treatment, p 0.0001). The effect of the single dose of antibody was short-lived, with CAA progression during the second week posttreatment occurring at a rate greater than control antibody-treated mice ( 0.84% per day versus 0.34% per day, p 0.028). Although our previous observations had not identified vascular branch points as regions particularly susceptible to CAA, we found that the effect of passive immunotherapy was greater in their immediate vicinity. Conclusion: These data demonstrate the ability of single-dose anti-A antibody exposure to cause temporary regression of CAA in Tg2576.