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O3–02–01: Experimental model of Type 3 diabetes–relevance to sporadic Alzheimer's disease
Author(s) -
Monte Suzanne M.,
Tong Ming,
Lester-Coll Nataniel,
Wands Jack R.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.196
Subject(s) - neurodegeneration , endocrinology , medicine , insulin receptor , biology , insulin , senile plaques , amyloid precursor protein , gliosis , gsk 3 , alzheimer's disease , insulin resistance , neuroscience , microbiology and biotechnology , signal transduction , disease
spinal fluid (CSF) biomarkers -amyloid peptide (A 1-42), total tau protein (tau) and tau phosphorylated at threonine 181 (P-tau181P) remains to be established compared to clinical diagnosis in autopsyconfirmed dementia subjects. Methods: A total of 100 CSF samples from demented patients with autopsy-confirmed pathological diagnoses were included. CSF levels of A 1-42, tau and P-tau181P were determined with commercially available single parameter ELISA kits (INNOTEST®). Results: Diagnostic accuracy of a biomarker model (using age-corrected CSF levels of A 1-42 and P-tau181P) differentiating Alzheimer’s disease (AD) from other dementias was 82.7% compared to 81.6% for clinical diagnosis, showing that this biomarker model gives the same information as a whole clinical work-up (including imaging). Using the biomarker-based model in cases with clinically doubtful diagnoses, a correct diagnosis would have been established in 4 of the 6 autopsy-confirmed AD cases and 3 of the 3 autopsy-confirmed cases with other dementias. Conclusions: This study showed the value of biomarkers in differential dementia diagnosis, using the gold standard (pathological diagnosis) as a reference. Diagnostic accuracy of a biomarker-based model is comparable to clinical diagnostic accuracy, and can help in establishing a correct diagnosis in case of doubtful clinical diagnoses.