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P4–143: Identification of the apoe receptor sorLA/LR11 as a novel component of hallmark Alzheimer's disease–related lesions in down syndrome
Author(s) -
Khoogar Leila,
Dodson Sara E.,
Shoemaker James T.,
Rees Howard D.,
Mufson Elliot,
Levey Allan I.,
Lah James J.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.1882
Subject(s) - senile plaques , neuropathology , astrocytosis , receptor , pathology , immunohistochemistry , hippocampus , cortex (anatomy) , alzheimer's disease , neuroscience , biology , medicine , disease , biochemistry
some deposits of magnetite which contain both Fe and Fe , a finding that has not been reported previously in the literature. The presence of magnetite was supported by the SQUID magnetometry data. An increasing microglial reaction which paralleled the iron accumulation in R6/2 brain tissue was found in some samples, though neither neuronal death nor atrophy was observed. Conclusions: Together, these observations provide a preliminary indication that alterations in iron deposition occur prior to pronounced neuronal cell death in the model of HD. In view of the neuronal damage caused by iron-catalyzed free radical formation, these alterations are likely to contribute to the vulnerability of striatal neurons. Therefore, early-onset iron deposition may be relevant to the pathogenesis of the disease.