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P4–127: CSF neurofilament light as a diagnostic and prognostic biomarker for amyotrophic lateral sclerosis
Author(s) -
Zetterberg Henrik,
Jacobsson Johan,
Rosengren Lars,
Blennow Kaj,
Andersen Peter M.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.1866
Subject(s) - amyotrophic lateral sclerosis , medicine , biomarker , gastroenterology , apolipoprotein e , disease , cerebrospinal fluid , multiple sclerosis , allele , pathology , oncology , immunology , biology , gene , biochemistry
levels of GDNF in the brains of scrapie-infected mice on the days of post-inoculation (dpi) of 100 and 160. In addition, we found that more intensive immunoreactivities of GDNF in the brains of scrapie-infected mice, specifically in the hippocampal astrocytes, than in those of control mice. Conclusions: This study suggest that up regulation of GDNF expression in scrapie-infected brain may play a function to protect the neuronal cell loss and astrophy in neurodegenerative disorders, which is one of the important role in the pathogenic mechanisms of prion diseases. Acknowledgment: This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea.