P4–127: CSF neurofilament light as a diagnostic and prognostic biomarker for amyotrophic lateral sclerosis | Zendy

Zetterberg Henrik | Zendy; Jacobsson Johan | Zendy; Rosengren Lars | Zendy; Blennow Kaj | Zendy; Andersen Peter M. | Zendy

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P4–127: CSF neurofilament light as a diagnostic and prognostic biomarker for amyotrophic lateral sclerosis

Author(s) -

Zetterberg Henrik,

Jacobsson Johan,

Rosengren Lars,

Blennow Kaj,

Andersen Peter M.

Publication year - 2006

Publication title -

alzheimer's and dementia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.713

H-Index - 118

eISSN - 1552-5279

pISSN - 1552-5260

DOI - 10.1016/j.jalz.2006.05.1866

Subject(s) - amyotrophic lateral sclerosis , medicine , biomarker , gastroenterology , apolipoprotein e , disease , cerebrospinal fluid , multiple sclerosis , allele , pathology , oncology , immunology , biology , gene , biochemistry

levels of GDNF in the brains of scrapie-infected mice on the days of post-inoculation (dpi) of 100 and 160. In addition, we found that more intensive immunoreactivities of GDNF in the brains of scrapie-infected mice, specifically in the hippocampal astrocytes, than in those of control mice. Conclusions: This study suggest that up regulation of GDNF expression in scrapie-infected brain may play a function to protect the neuronal cell loss and astrophy in neurodegenerative disorders, which is one of the important role in the pathogenic mechanisms of prion diseases. Acknowledgment: This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea.

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