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P4–108: Hereditary dysphasic disinhibition dementia 2 is a chromosome 17q21–linked frontotemporal lobar degeneration with ubiquitin–positive, tau–negative inclusions
Author(s) -
Cairns Nigel J.,
Tu Pang-hsien,
Pastor Pau,
Norton Joanne,
Chakraverty Sumitra,
Mukherjee Odity,
Carter Deborah,
Behrens Maria I.,
Morris John C.,
Goate Alison
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.1847
Subject(s) - pathology , frontotemporal lobar degeneration , atrophy , neuropathology , frontotemporal dementia , dementia , medicine , disease
the hippocampus of the Mongolian gerbil after ischemic insult. Methods: We observed for the first time that the rpS3 immunoreactivity was increased in the hippocampus after transient forebrain ischemia and the RT-PCR analysis also indicates that the mRNA was significantly increased in the hippocampus 6 h after transient forebrain ischemia. To elucidate the role of rpS3 on ischemic damage, we developed the delivery vector. Results: PEP-1 the PEP-1-rpS3 treatment significantly increased the neuronal survival against ischemic damage and reduced TUNEL positive neurons in the hippocampal CA1 region dose-dependently. Conclusions: This result suggests that rpS3 significantly reduces the DNA fragmentation induced by ischemic damage.