P4–056: Translational regulation of ADAM10 expression | Zendy

Buell Dominik | Zendy; Ludwig Ann-Kathrin | Zendy; Zilow Sonja | Zendy; Prinzen Claudia | Zendy; Fahrenholz Falk | Zendy; Haass Christian | Zendy; Lammich Sven | Zendy

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P4–056: Translational regulation of ADAM10 expression

Author(s) -

Buell Dominik,

Ludwig Ann-Kathrin,

Zilow Sonja,

Prinzen Claudia,

Fahrenholz Falk,

Haass Christian,

Lammich Sven

Publication year - 2006

Publication title -

alzheimer's and dementia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.713

H-Index - 118

eISSN - 1552-5279

pISSN - 1552-5260

DOI - 10.1016/j.jalz.2006.05.1794

Subject(s) - adam10 , untranslated region , amyloid precursor protein , ectodomain , five prime untranslated region , biology , alpha secretase , hek 293 cells , microbiology and biotechnology , gene isoform , three prime untranslated region , metalloproteinase , messenger rna , gene , disintegrin , alzheimer's disease , genetics , receptor , matrix metalloproteinase , medicine , disease

deposition first and then amyloid plaque formation in transgenic mice. Conclusions: The slight cognitive impairment observed in pre-plaque aged mice, sustain the hypothesis for a pathological function of the overexpressed non-aggregated intracellular amyloid. Moreover, these findings evidence for the first time a causal correlation between hyperhomocysteinemia and AD and suggest a molecular mechanism for the onset of sporadic AD.

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