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P4–056: Translational regulation of ADAM10 expression
Author(s) -
Buell Dominik,
Ludwig Ann-Kathrin,
Zilow Sonja,
Prinzen Claudia,
Fahrenholz Falk,
Haass Christian,
Lammich Sven
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.1794
Subject(s) - adam10 , untranslated region , amyloid precursor protein , ectodomain , five prime untranslated region , biology , alpha secretase , hek 293 cells , microbiology and biotechnology , gene isoform , three prime untranslated region , metalloproteinase , messenger rna , gene , disintegrin , alzheimer's disease , genetics , receptor , matrix metalloproteinase , medicine , disease
deposition first and then amyloid plaque formation in transgenic mice. Conclusions: The slight cognitive impairment observed in pre-plaque aged mice, sustain the hypothesis for a pathological function of the overexpressed non-aggregated intracellular amyloid. Moreover, these findings evidence for the first time a causal correlation between hyperhomocysteinemia and AD and suggest a molecular mechanism for the onset of sporadic AD.