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P4–026: The nature of monoclonal antibodies produced from mice immunized with Aβ protofibrils
Author(s) -
Pettersson Frida E.,
Sehlin Dag,
Englund Hillevi,
Hedlund Marie,
Pauli Staffan,
Lannfelt Lars
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.1764
Subject(s) - monoclonal antibody , antibody , western blot , antigen , chemistry , microbiology and biotechnology , monoclonal , biology , biochemistry , immunology , gene
of the ADAM protease family and the MT-MMP (membrane-type matrix metalloproteinase) family. Conclusions: Regulation of Alc cleavage was not conserved across the various members of the family proteins, suggesting that multiple “Alc secretases” may participate in Alc processing. However, like APP C-terminal fragments (CTFs), the Alc CTFs that remain cell-associated following ectodomain shedding rapidly underwent -secretase-type cleavage. The characterization of the processing of Alc is important for investigating the possiblility that aberrant processing of Alc family members may play a role in AD.