P4–026: The nature of monoclonal antibodies produced from mice immunized with Aβ protofibrils | Zendy

Pettersson Frida E. | Zendy; Sehlin Dag | Zendy; Englund Hillevi | Zendy; Hedlund Marie | Zendy; Pauli Staffan | Zendy; Lannfelt Lars | Zendy

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P4–026: The nature of monoclonal antibodies produced from mice immunized with Aβ protofibrils

Author(s) -

Pettersson Frida E.,

Sehlin Dag,

Englund Hillevi,

Hedlund Marie,

Pauli Staffan,

Lannfelt Lars

Publication year - 2006

Publication title -

alzheimer's and dementia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.713

H-Index - 118

eISSN - 1552-5279

pISSN - 1552-5260

DOI - 10.1016/j.jalz.2006.05.1764

Subject(s) - monoclonal antibody , antibody , western blot , antigen , chemistry , microbiology and biotechnology , monoclonal , biology , biochemistry , immunology , gene

of the ADAM protease family and the MT-MMP (membrane-type matrix metalloproteinase) family. Conclusions: Regulation of Alc cleavage was not conserved across the various members of the family proteins, suggesting that multiple “Alc secretases” may participate in Alc processing. However, like APP C-terminal fragments (CTFs), the Alc CTFs that remain cell-associated following ectodomain shedding rapidly underwent -secretase-type cleavage. The characterization of the processing of Alc is important for investigating the possiblility that aberrant processing of Alc family members may play a role in AD.

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