P3–435: Inhibition of protein phosphatases induces impairment in axonal transport and spatial memory retention | Zendy

Yang Ying | Zendy; Yang Xifei | Zendy; Tian Qing | Zendy; Wang Xiaochuan | Zendy; Li Hong-Lian | Zendy; Wang Qun | Zendy; Wang Jianzhi | Zendy

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P3–435: Inhibition of protein phosphatases induces impairment in axonal transport and spatial memory retention

Author(s) -

Yang Ying,

Yang Xifei,

Tian Qing,

Wang Xiaochuan,

Li Hong-Lian,

Wang Qun,

Wang Jianzhi

Publication year - 2006

Publication title -

alzheimer's and dementia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.713

H-Index - 118

eISSN - 1552-5279

pISSN - 1552-5260

DOI - 10.1016/j.jalz.2006.05.1706

Subject(s) - hyperphosphorylation , neurofilament , axoplasmic transport , phosphatase , hippocampus , cytoskeleton , microbiology and biotechnology , neuroscience , hippocampal formation , tau protein , chemistry , western blot , morris water navigation task , biology , phosphorylation , alzheimer's disease , medicine , biochemistry , immunohistochemistry , immunology , cell , disease , gene

observed spines) resulting in no net change in spine density; however in aged Tg2576 mice, this balance is disrupted. Spine elimination is increased 3 fold in these mice to almost 15%, while spine formation remains normal, resulting in the observed net loss of spines. These effects are exacerbated near plaques. Conclusions: Together, these data imply that dense-cored amyloid plaques have a synaptotoxic effect resulting in altered structural plasticity. Supported by: NIH grants AG08487, AG00277, and Alzheimer’s Association Pioneer Award EB00768.

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