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P3–382: Peripheral anti–oxidant defense, cognitive performance and survival in Alzheimer's disease patients
Author(s) -
Minghetti Luisa,
Greco Anita,
Puopolo Maria,
Combrinck Marc,
Warden Donald,
Smith David A.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.1652
Subject(s) - oxidative stress , disease , cognition , peripheral , medicine , cognitive decline , alzheimer's disease , pathogenesis , cognitive impairment , oncology , immunology , dementia , psychiatry
late-onset Alzheimer’s disease (AD) were investigated to investigate correlation between their levels. Methods: A group of 40 patients with sporadic late-onset Alzheimer’s disease and relevant amount of control (40) were examined. The DSM IV criteria were used as diagnostic criteria for dementia Alzheimer’s type. MMSE was used to assess cognitive impairment in examined groups. Paraoxonase activity was measured spectrophotometrically (substrate-phenyl acetate). The enzyme activity was expressed in the international units per ml of serum (U/ml). HDL, LDL and triglycerides levels were measured in human’s sera and expressed as mg/dl and mmol/l. Results: In AD group the level was significantly different as compared to control group (70.78 58.15 U/ml vs. 89.78 22.38 U/ml). The results were positively correlated with MMSE and HDL level. We didn’t found any correlation with level of LDL cholesterol and triglycerides. LDL levels, however, were or higher then norm or they were at the high and of a normal range. Conclusion: Despite the fact implication of vascular factors in Alzheimer-type dementia (ATD) is strongly suspected, the activity of paraoxonase may be an independent risk factor for late-onset AD.