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P3–351: Changes in noradrenergic innervation to hippocampus and prefrontal cortex of Alzheimer's subjects with and without lewy bodies
Author(s) -
Szot Patricia,
White Sylvia S.,
Greenup J. Lynne,
Leverenz James B.,
Peskind Elaine R.,
Raskind Murray A.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.1621
Subject(s) - locus coeruleus , autoreceptor , hippocampus , neuroscience , prefrontal cortex , neocortex , medicine , endocrinology , forebrain , chemistry , biology , receptor , central nervous system , serotonin , cognition
roles in neuronal vulnerability in neurodegenerative diseases?” Methods: We sought to examine the first question using quantitative expression of GluR1 and GluR2 subunit proteins in HEK293 cells by electrophysiological studies, and for second question, we tested the editing efficiency at the Q/R site of GluR2 mRNA in the brain areas of several neurodegenerative diseases, such as Alzheimer’s disease, amyotrophic lateral sclerosis, Pick’s disease, dentatorubral pallidoluysian atrophy, Huntington disease, Machado-Joseph disease, and multiple system atrophy. Conclusions: The results obtained from this study indicate the selective expression of heteromeric receptors, and are compatible with an equilibrium model of assembly of tetramers as pairs of identical heteromeric dimers. We found that editing efficiency is decreased in ventral horn neurons in amyotrophic lateral sclerosis patients, but unchanged in other diseases. These results indicate that contribution of Ca permeable AMPA receptors induced excitotoxity on neuronal vulnerability is varied in typical neurodegenerative diseases.