P3–236: Enzymes in neurodegeneration. Peptidyl arginine deiminase II in etiology and pathogenesis of Alzheimer's disease | Zendy

Whiteley Chris | Zendy; Louw Cassandra | Zendy; Bradley Graeme | Zendy

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P3–236: Enzymes in neurodegeneration. Peptidyl arginine deiminase II in etiology and pathogenesis of Alzheimer's disease

Author(s) -

Whiteley Chris,

Louw Cassandra,

Bradley Graeme

Publication year - 2006

Publication title -

alzheimer's and dementia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.713

H-Index - 118

eISSN - 1552-5279

pISSN - 1552-5260

DOI - 10.1016/j.jalz.2006.05.1505

Subject(s) - arginine deiminase , arginine , pathogenesis , neurodegeneration , citrulline , medicine , biochemistry , disease , biology , pathology , amino acid

Western blotting, we show that these lysosomes contain APP co-localized with and the gamma secretase proteins nicastrin, presenilin-1, mAph1 and Pen2 and gamma secretase activity. Conclusions: This work demonstrates the usefulness of Free Flow Electrophoresis as a tool to study gammasecretase proteins and activity and reinforces the importance of the endosomal/ lysosomal system in the generation of beta amyloid.

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