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P3–236: Enzymes in neurodegeneration. Peptidyl arginine deiminase II in etiology and pathogenesis of Alzheimer's disease
Author(s) -
Whiteley Chris,
Louw Cassandra,
Bradley Graeme
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.1505
Subject(s) - arginine , arginine deiminase , pathogenesis , neurodegeneration , citrulline , biochemistry , medicine , disease , biology , chemistry , pathology , amino acid
Western blotting, we show that these lysosomes contain APP co-localized with and the gamma secretase proteins nicastrin, presenilin-1, mAph1 and Pen2 and gamma secretase activity. Conclusions: This work demonstrates the usefulness of Free Flow Electrophoresis as a tool to study gammasecretase proteins and activity and reinforces the importance of the endosomal/ lysosomal system in the generation of beta amyloid.