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P3–220: Test of PI3K/Akt signaling hypothesis for mechanism of AD using unique PS1 FAD mutations that do not affect Aβ42 production
Author(s) -
Shioi Junichi,
Dolcini Virginia,
Baki Lia,
Mehta Pankaj,
Georgakopoulos Tassos,
Robakis Nikolaos K.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.1489
Subject(s) - protein kinase b , phosphorylation , pi3k/akt/mtor pathway , gsk 3 , microbiology and biotechnology , biology , signal transduction , chemistry , cancer research
periphery. Over-expression of the sensors did not result in any detectable toxicity since cells were able to divide successfully and no morphological changes could be revealed. Conclusion: Using this approach, a better temporal and spatial understanding of the apoptotic processes will be achieved. This is necessary in order to identify therapeutic targets to prevent the massive loss of neurons in AD and related disorders.