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P3–216: Hyperphosphorylation of tau renders the cells more resistant to apoptosis induced by staurosporine
Author(s) -
Wang Hai-Hong,
Wang Jian-Zhi
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.1485
Subject(s) - staurosporine , neurodegeneration , hyperphosphorylation , transfection , tau protein , gsk 3 , apoptosis , microbiology and biotechnology , chemistry , kinase , biology , protein kinase c , alzheimer's disease , biochemistry , medicine , gene , disease
CaMKII inhibitor KN-62 have no effects on control cells, but sensitize AD cells to death induced by serum withdrawal and increased ERK1/2 phosphorylation, and iv) no apoptotic effects of CaM antagonists were observed in AD cells treated with PD098059. These results suggest the existence of an activation threshold of the ERK1/2 pathway setting by Ca2 /CaMdependent mechanisms, which appears to be the critical factor controlling cell survival or death decision under trophic factor withdrawal.