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P3–202: Activation of estrogen receptor α increases and estrogen receptor β decreases apolipoprotein E expression in hippocampus in vitro and in vivo
Author(s) -
Wang Jun Ming,
Irwin Ronald,
Brinton Roberta D.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.1471
Subject(s) - apolipoprotein e , estrogen receptor , estrogen , endocrinology , agonist , medicine , estrogen receptor beta , hippocampal formation , estrogen receptor alpha , biology , receptor , in vivo , chemistry , disease , genetics , cancer , breast cancer
gene status and gene dose. Results: ApoE4 gene status did not reveal any significant differences in the lipid profile except for LDL. However, significant differences were observed by ApoE gene dose. Conclusions: ApoE gene status has minimal influence on the lipid panel or mean age in AD. Apo E gene dose does influence the lipid panel with Apo E 2/2, and 2/3 having significantly better lipid panels and older age of onset.