P3–202: Activation of estrogen receptor α increases and estrogen receptor β decreases apolipoprotein E expression in hippocampus  in vitro  and  in vivo | Zendy

Wang Jun Ming | Zendy; Irwin Ronald | Zendy; Brinton Roberta D. | Zendy

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P3–202: Activation of estrogen receptor α increases and estrogen receptor β decreases apolipoprotein E expression in hippocampus in vitro and in vivo

Author(s) -

Wang Jun Ming,

Irwin Ronald,

Brinton Roberta D.

Publication year - 2006

Publication title -

alzheimer's and dementia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.713

H-Index - 118

eISSN - 1552-5279

pISSN - 1552-5260

DOI - 10.1016/j.jalz.2006.05.1471

Subject(s) - apolipoprotein e , estrogen receptor , estrogen , endocrinology , agonist , medicine , estrogen receptor beta , hippocampal formation , estrogen receptor alpha , biology , receptor , in vivo , chemistry , disease , genetics , cancer , breast cancer

gene status and gene dose. Results: ApoE4 gene status did not reveal any significant differences in the lipid profile except for LDL. However, significant differences were observed by ApoE gene dose. Conclusions: ApoE gene status has minimal influence on the lipid panel or mean age in AD. Apo E gene dose does influence the lipid panel with Apo E 2/2, and 2/3 having significantly better lipid panels and older age of onset.

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