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P3–140: The effect of antihypertensive medication use on age–related cognitive decline
Author(s) -
Yasar Sevil,
Zhou Jing,
Xue Qian-Li,
Fried Linda P.,
Carlson Michelle
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.1408
Subject(s) - dementia , medicine , cognitive decline , blood pressure , vascular dementia , population , antihypertensive drug , disease , epidemiology , gerontology , environmental health
search Council Cognitive Functioning and Ageing Study a communitybased, prospective cohort study comprising 13,004 participants aged 65 and over. Participants were randomly selected through General Practice Registers in 5 geographical areas across England and Wales. After initial baseline screening of 13,004 participants, a sub-sample (N 2640) completed an in-depth assessment, including the Geriatric Mental State Examination. Responses were used to generate a diagnosis of both depression and dementia using the AGECAT algorithm. Results: 25.1% (95% C.I. 19.2-31.0) of participants with dementia also had a diagnosis of clinical depression. This amounted to 3.5% (95% C.I. 2.8-4.2) of the total sample. In the sub-sample of people with dementia, there was an association between depression and younger age group (p trend 0.02), high functional disability (p trend 0.02), and comorbid medical illnesses (p trend 0.02). Depression was not related to sex, social class, education or living in a deprived area. Conclusion: Depression is common in people with dementia, particularly in younger participants however, this finding may be due in part to the inability of older patients with more severe dementia to articulate their feelings. Those with other chronic medical conditions are also at particular risk.