Premium
P3–124: Selenium and cognitive function in rural elderly Chinese
Author(s) -
Gao Sujuan,
Liang Chaoke,
Hall Kathleen S.,
Jin Yinlong,
Unverzagt Frederick W.,
Ji Rongdi,
Murrell Jill,
Cao Jingxiang,
Shen Jianzhao,
Ma Feng,
Matesan Janetta,
Ying Bo,
Cheng Yibing,
Hendrie Hugh C.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.1392
Subject(s) - selenium , glutathione peroxidase , medicine , selenium deficiency , cognition , gerontology , environmental health , psychiatry , oxidative stress , superoxide dismutase , chemistry , organic chemistry
derly subjects, 906 households were eligible and 682 subjects participated. Subjective memory complaints were assessed by subjective memory complaint questionnaire (SMCQ), which consists of 14 items reflecting general memory function and everyday memory function. Variables associated with SMC including cognitive function, depressive symptoms, hearing impairment and daytime sleepiness were evaluated by trained research nurses using Geriatric Health Assessment Package (GHAP). Bivariate associations between SMCQ and clinical variables were investigated using simple linear regression analysis. To determine which variables were independently associated with SMCQ and its two subscales, stepwise multiple linear regression analysis was performed for each scale. Results: The following were associated with SMC in simple linear regression analysis: cognitive function, depressive symptoms, visual and hearing impairment, excessive daytime sleepiness, activities of daily living function, history of urinary incontinence, fall and pain (p 0.05). In stepwise multiple linear regression analysis, excessive daytime sleepiness and hearing impairment were independently and consistently associated with SMC after controlling for objective cognitive function and depressive function. Moreover, these noncognitive variables were stronger predictors of SMC than objective cognitive function. Conclusions: Among elderly subjects in the general population, noncognitive variables including daytime sleepiness and hearing impairment were associated with SMC independent of depression and objective cognitive function. Moreover, association of SMC with daytime sleepiness and hearing impairment was stronger than that of cognitive function. Our results suggested that SMC are not a simple reflection of objective cognitive function. Thus, clinicians should carefully evaluate the multiple noncognitive domains when elderly subjects report memory complaints.