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P3–114: Longitudinal predictors of dementia in a diabetic cohort
Author(s) -
Bruce David G.,
Casey Genevieve,
Davis Wendy A.,
Almeida Osvaldo,
Clarnette Roger,
Foster Jonathon,
Davis Timothy M.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.1382
Subject(s) - medicine , dementia , diabetes mellitus , cohort , logistic regression , longitudinal study , neurocognitive , stroke (engine) , cohort study , physical therapy , disease , cognition , psychiatry , endocrinology , pathology , mechanical engineering , engineering
dardized methods. Values of Hcy, folate and vitamin B12 were logtransformed to approximate normal distribution. Results: The crude odds ratio (OR) for dementia was elevated fivefold for each log-unit elevation of Hcy (OR 4.9; 95% CI: 3.4-7.1; p 0.0001). After adjusting for sex, age, education, folate, vitamin B12 and APOE genotype, the risk of dementia was somewhat reduced, but remained significant with an OR of 3.4 (95% CI: 2.2-5.4; p 0.0001). Further, we observed that individuals with Hcy level above the 90th percentile for their age and sex had OR 1.9 (p 0.001). To account for the non-linear effect associated with age, we then stratified the sample into 2 cohorts (using 66 years as cut point (median age)) and estimated the risk for dementia in individuals with Hcy level above the 90th percentile. Hcy above the 90th percentile was found to be a much stronger predictor of dementia for the younger group (OR 3.4; 95% CI:1.2-9.1), compared with the older group (OR 1.8; 95% CI:1.1-2.7). Further, elevated Hcy was a significant risk factor for VaD (OR 4.5; 95% CI:1.9-10.8; p 0.001), but not for AD in this population. Conclusions: In the current study of Venezuelan cohort, Hcy is an important predictor of dementia, especially in younger individuals. Further, it is a strong predictor of VaD, but not AD.