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P3–033: Development of a tool for the global assessment of progression and change in dementia: The G–APROACH–D – phase 1 (assessment of global change in dementia)
Author(s) -
Bullock Roger,
Voss Sarah
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.1300
Subject(s) - dementia , psychology , cognition , psychological intervention , disease , clinical psychology , gerontology , medicine , psychiatry
the same subcategory of animals (eg. farm animals). The number of switches (transitions between clusters) and cluster size (number of words within a cluster) were calculated. Results: Statistical analysis has confirmed that total word production was significantly reduced 5 years before dementia incidence. Cluster size in premorbid subjects was significantly lower than in controls only at the dementia incidence while number of switches was already lower in the preclinical phase of dementia. Conclusions: These preliminary results suggest that switching processes decline earlier than clustering processes in the course of AD. Therefore, the diminished fluency performances of future AD subjects would be explained by an impairment of cognitive flexibility rather than by degraded semantic storages while in the clinical phase both phenomena are impaired.