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P3–018: Difference of amnestic pattern in MCI patients with and without subcortical vascular disease: Preliminary study
Author(s) -
Shim Yong Soo,
Yang Dong Won
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.1285
Subject(s) - geriatric depression scale , vascular dementia , dementia , depression (economics) , cognitive impairment , mini–mental state examination , memory impairment , psychology , medicine , recall , audiology , cardiology , cognition , disease , psychiatry , depressive symptoms , cognitive psychology , economics , macroeconomics
Background: Mild cognitive impairment (MCI) has the clinical and etiological heterogeneity. Therefore it is difficult to predict into which type of dementia MCI progresses. Whereas Alzheimer’s disease (AD) shows prominently the defect of memory encoding and storage, the impaired retrieval is associated with the subcortical dementia such as vascular dementia (VaD). Objectives: We investigated the patterns of memory deficit in Seoul Verbal Learning Test (SVLT) between vascular MCI (vMCI) and non-vascular MCI (nvMCI) by the Erkinjuntti’s imaging criteria. Methods: Among 70 MCI patients by the Petersen’s criteria visiting the Memory Clinic of St. Mary’s Hospital, 49 MCI patients (including 24 nvMCIs and 25 vMCIs) were evaluated. They were performed by the Korean mini-mental state examination (K-MMSE), the geriatric depression scale (GDS), the Korean instrumental activity of daily living (K-IADL) and Hachinski’s ischemic scale (HIS), and by the SVLT for memory test. MRI was performed for excluding the other causes such as tumor and trauma and for subdivision into vMCI and nvMCI by Erkinjuntti’s imaging criteria. The differences of the SVLT parameters were compared between vMCI and nvMCI. Results: Between the two groups, the distribution of age, sex, education level, K-MMSE score, K-IADL score, and GDS score were not different. HIS score was higher in vMCI (5.00 2.62) than that of nvMCI (1.72 2.11). Pattern analysis of the SVLT performance revealed that the scores of the true positive recognition, the discrimination index and the combination index (total recall plus discrimination index) were higher in vMCI (p 0.002, 0.02 and 0.05, respectively). Although not statistically significant, nvMCI patients recalled fewer words than vMCI patients. vMCI patients showed better recognition than nvMCI patients. Conclusions: This finding suggests that vMCI, compared to nvMCI has the retrieval dysfunction with little disturbance of recall (encoding and storage), which is similar to the memory dysfunction of VaD. When the further clinical studies are added, the Erkinjuntti’s imaging criteria may be useful for the subclassification of MCI patients as the predictor of the progression into the AD or VaD.