P3–003: Neuropsychological clusters differentiate subgroups of vascular dementia from Alzheimer's disease and MCI

Objectives: This research was undertook to study the correlation between two tools for cognitive evaluation, Mini-mental State Examination-severe (MMSE-s) and Severe Impairment Battery (SIB) and the Bristol Daily Activities Functional Scale and the correlation between Bristol Scale and the conventional MMSE. Our hypothesis is that the MMSE-s and SIB have a better correlation with functional performance than MMSE in patients with moderately severe to severe dementia. To this end we did a stratification of scores for all the above scales. Methods: 50 patients from the Behavioral Neurology Section EPM-UNIFESP were evaluated. Mean age was 76.8 7.9 (range 57 to 95) and 32% were males; mean education was 5.0 2.3 years (range 4 to 15); mean disease duration was 3.9 1.5 years (range 2 to 10). All patients completed all four scales. Results: Preliminary results in a small sample drawn from the study group do indicate a difference between the three cognitive scales. SIB and MMSE-s had a better correlation with functional score than MMSE, and MMSE-s had a correlation slightly better than SIB. Conclusions: These data indicate that it is possible a follow up of dementia patients up to severe stage as long as adequate instruments are used. On the other hand, conventional tools like MMSE might not have a correlation with functional status, and thus might not reflect patient’s daily life.