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P2–368: Atrophy in the parietotemporal regions increases the risk of developing Alzheimer's disease: A longitudinal MRI study
Author(s) -
Desikan Rahul S.,
Han Xiao,
Cabral Howard J.,
Fischl Bruce,
Blacker Deborah,
Guttmann Charles R.,
Albert Marilyn S.,
Killiany Ronald J.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.1208
Subject(s) - atrophy , neuropathology , medicine , neuroimaging , temporal lobe , alzheimer's disease , brain size , magnetic resonance imaging , hyperintensity , pathology , disease , radiology , psychiatry , epilepsy
uniformity [1], linearly registered into stereotaxic space [2] and tissue classified [3]. Subsequently, the inner and outer cortical surfaces were extracted [4], cortical thickness between these surfaces was measured in native-space mm and blurred with a 20mm diffusion-smoothing kernel [5]. All 40,962 vertices across the entire cortex underwent mixed-model analysis testing for thickness differences by diagnosis and interactions between follow-up scan interval and diagnosis. Multiple comparisons were accounted for using a 5% False Discovery Rate threshold [6]. Results: Cortical thickness was significantly different between AD and HC subjects in the medial frontal lobes, the posterior superior temporal gyri, the anterior cingulates, and, most significantly, the medial temporal lobes. The AD cohort had significantly greater decline than the HCs in the inferior temporal gyrus, the anterior cingulate, the orbitofrontal cortices, and the superior temporal gyri. Conclusion: The results, especially in the medial temporal lobes, show a progression from medial to lateral with follow-up (see figure). There is a large base-line difference in cortical thickness in the entorhinal cortex (0.7mm), the decline with follow-up in the AD group is 0.2mm/year. Moving laterally to the inferior temporal gyrus, there is little group difference initially, but a 0.45mm/year decline in thickness in the AD group. This suggests that the areas involved earliest in the disease, such as the entorhinal cortex, will have already undergone the most significant thinning, whereas areas involved later will exhibit greater thinning at follow-up.