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P2–363: Omega–3 fat use to stimulate brain perfusion for early diagnosis of dementia and possible therapy
Author(s) -
Pretorius Harold T.,
Kircher Christorpher,
Idoine John D.,
Pagani Luis F.,
Harrell Michael F.,
Arias Jose A.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.1203
Subject(s) - medicine , perfusion , dementia , perfusion scanning , nuclear medicine , cardiology , endocrinology , disease
(defined here as CDR 0.5) and a CDR Sum-of-Boxes (CDR-SB) between 0.5 and 3.5 at the time of scanning (baseline). During scanning, subjects performed a visual scene-encoding paradigm (Dickerson BC et al., Ann Neurol 2004). fMRI data were analyzed (SPM2) using an ROI approach in which a mask was created of hippocampal clusters showing differential activation in the Novel vs. Repeated (NvR) contrast at the group level. Clusters were included in the mask if voxels within the cluster were significant at p .005 (uncorrected) and the cluster itself was significant at p .05 (small-volume correction). Hippocampal activation was quantified by extracting the SPM parameter estimate of NvR from this mask from each individual’s data. A linear regression model was created to predict degree of future cognitive decline (change in CDR-SB score after scanning) from baseline age, CDR-SB, and hippocampal activation. Partial correlations were run to examine the effect of each variable, controlling for the others. Results: The decline in CDR-SB after scanning ranged from 0 to 4.5 points (mean 1.88, S.D. 1.45). The linear regression model predicted cognitive decline (p .04), and partial correlation analyses revealed an effect of left hippocampal activation, controlling for the other predictors (r 0.53, p .006). Conclusions: These results suggest that fMRI may be a useful tool for predicting subsequent cognitive decline in individuals with MCI. Within a group of individuals with MCI spanning a range of mild impairment in daily life, greater hippocampal activation at the time of scanning predicted a greater degree of future cognitive decline.