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P2–351: Role of magnetization transfer imaging in early diagnosis of Alzheimer's disease
Author(s) -
Kabani Noor Jehan,
Dorr Adrienne,
Sled John G.,
Chertkow Howard
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.1191
Subject(s) - entorhinal cortex , alzheimer's disease , dementia , receiver operating characteristic , hippocampus , likelihood ratios in diagnostic testing , hippocampal formation , psychology , medicine , nuclear medicine , disease , cardiology , neuroscience
mation based morphometry [1] and investigated the relationship between brain structure at baseline and future cognitive decline. Baseline deformation maps were dependent variables in regression analyses, and independent variables included annualized cognitive change, cognitive score at baseline, head size, age, and group. Separate regressions were computed for change in MMSE, CDR, and for the following California Verbal Learning Test subtests: short and long delay cued recall (SDCR and LDCR), and immediate and short delay free recall (IDFR and SDFR). Results: The figure (right brain is image left) shows T-statistic maps overlaid on the group average spatially normalized MRI. A negative association between structure and cognitive change on SDCR is shown in (a), where reduced tissue volumes in the left ERC at baseline are associated with greater performance decline. Smaller tissue volumes in the hippocampus at baseline were also related to greater declines in SDCR, as shown in (b). Associations between structure and LCDR were similar. Panel (c) shows reduced tissue volume in the posterior cingulate cortex at baseline is associated with greater decline in SDFR; adjacent white matter and left ERC were also implicated. These regions were less significantly associated with decline on IDFR. Smaller volumes of frontal and parietal white matter at baseline were associated with MMSE decline. Future declines in CDR were related to smaller baseline volumes of frontal and parietal lobes, particularly in the precuneus region (d). Conclusions: Deformation morphometry reveals focal brain atrophy on MRI that predicts future cognitive decline, and may allow earlier and more precise separation of normal aging from early Alzheimer’s disease. [1] C. Studholme et al, NeuroImage, Vol 21 (2004), pp 1387-1398.