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P2–344: PIB deposition in frontotemporal dementia in comparison with Alzheimer‘s disease and healthy volunteers: A PET study
Author(s) -
Frizell Santillo Alexander,
Engler Henry,
Kilander Lena,
Wang S.X.,
Lindau Maria,
Lannfelt Lars,
Långström Bengt
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.1184
Subject(s) - pittsburgh compound b , frontotemporal dementia , nuclear medicine , medicine , dementia , alzheimer's disease , psychology , white matter , analysis of variance , pons , pathology , cardiology , magnetic resonance imaging , disease , radiology
studies have found a reduction of the neuronal marker N-acetyl-aspartate (NAA) in Alzheimer’s Disease (AD) and a few have reported similar findings in mild cognitive impairment (MCI). Objective: Within the German Network on Dementia, we conduct a multicenter 1H-MRS study with four participating sites. Methods: We implemented a single voxel 1HMRS protocol of the medial temporal lobe (MTL) which included H20 unsuppressed sequences to quantify the metabolites against tissue water. At present over 200 patients with either dementia or MCI plus control subjects are included in the study. Results: At the current state of analysis, we have observed unsystematic center-effects for all metabolites except myo-inositol (MI). Taking this into account, NAA is lower in MCI and dementia patients compared to controls. NAA/Cr and NAA/MI are not significantly different between patients and controls. None of the metabolites or metabolic ratios differs between MCI and dementia patients. There is, however, a highly significant difference between these groups in the amount of brain tissue in the voxels, indicated greater MTL atrophy in dementia than in MCI. The ApoE-genotype does not affect any metabolite. Conclusions: At present, the dataset mainly provides evidence for two points. First, NAA seems to be superior compared with MI, NAA/Cr or MI/NAA in the separation of patients and controls. Second, the NAA reduction occurs prior to structural atrophy in the development of dementia.