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P2–336: Hippocampal size predicts conversion to Alzheimer's disease in MCI patients
Author(s) -
Pawlak Mikolaj A.,
Gulczynska Dorota,
Pruchnik-Wolinska Danuta,
Kozubski Wojciech
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.1176
Subject(s) - neurocognitive , hippocampus , dementia , alzheimer's disease , medicine , hippocampal formation , logistic regression , clinical dementia rating , depression (economics) , cognitive decline , psychology , pediatrics , disease , cognition , psychiatry , economics , macroeconomics
Background: Onset of Alzheimer’s disease (AD) is often preceded by period of mild cognitive impairment (MCI). However not all patients with MCI develop AD. Identification of risk factors responsible for the development of dementia in this group of patients may enable early introduction of treatment and delay the onset of dementia. Objective: To determine the influence of hippocampal volume on the risk of onset of AD in patients with MCI during a two year period of observation. Methods: We followed 19 patients (10 women, 9 men; age 68 7 years) with MCI (CDR 0.5) without depression and not treated with cholinesterase inhibitors for two years. Assessment of hippocampal volume was based on MRI study performed at the first timepoint of study period. Results: After a two year follow-up period patients were assigned to two groups on the basis of clinical and neurocognitive outcome. First group consisted of MCI patients who progressed to AD after follow-up period (CDR 1; 11 patients; 7 women, 4 men) and second group consisted of patients who had stable symptoms of MCI (CDR 0.5; 8 patients; 3 women, 5 men). The relationship between hippocampal volume z-score and risk of developing AD over two-year period of observation adjusted for age and sex interaction in logistic regression model was Rsquare 0.65; p 0.045 for left hippocampus and Rsquare 0.56; p 0.055 for right hippocampus. Conclusions: Initial hippocampal volume may influence the dynamics of cognitive decline in MCI patients over two year period of observation. The difference of effect between sides suggest higher sensitivity of left hippocampal volume as a predictive marker of AD . However lack of normative values of hippocampal volume mean and SD for elderly population limits calculated z-score to studied population.