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P2–320: 18F–labeled ethenyl–benzoxazole derivatives for in vivo detection of amyloid plaques in the brain
Author(s) -
Okamura Nobuyuki,
Furumoto Shozo,
Ito Satoshi,
Fujikawa Yousuke,
Tashiro Manabu,
Funaki Yoshihito,
Akatsu Hiroyasu,
Yamamoto Takayuki,
Iwata Ren,
Arai Hiroyuki,
Yanai Kazuhiko,
Kudo Yukitsuka
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.1160
Subject(s) - in vivo , senile plaques , biodistribution , chemistry , amyloid (mycology) , pathology , in vitro , benzoxazole , imaging agent , alzheimer's disease , medicine , biochemistry , biology , disease , microbiology and biotechnology , organic chemistry
pocampus over the occipital lobe were applied to the early cases as the markers of differential diagnosis. The hippocampus/occipital lobe ratio revealed to be the most accurate marker for the differential diagnosis of early AD and DLB (cutoff value 0.65, sensitivity 95%, specificity 80%). Conclusions: The hippocampus/occipital lobe ratio of FDG-PETmay be a useful marker for the differential diagnosis of AD and DLB in the early stage.