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P2–306: Patterns of atrophy in confirmed cases of sporadic and familial Alzheimer's disease: A voxel–based morphometric study
Author(s) -
Scahill Rachael I.,
Godbolt Alison K.,
Whitwell Jennifer L.,
Knight William D.,
Schott Jonathan M.,
Warren Jason D.,
Rossor Martin N.,
Fox Nick C.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.1146
Subject(s) - atrophy , grey matter , voxel based morphometry , pathology , voxel , neuropsychology , alzheimer's disease , posterior cortical atrophy , white matter , disease , medicine , psychology , neuroscience , magnetic resonance imaging , dementia , cognition , radiology
and GF-109203X (a specific inhibitor of protein kinase C) and forskolin (a specific cAMP-dependent protein kinase A activator) into the left ventricle of rat brains to produce tau hyperphosphorylation (partially reported by us in 2003, 2004). The level of tau phosphorylation was detected by Western blot and immunohistochemistry, Morris water Maze test was carried out to evaluate the behavioral change. H MRS was performed to measure ACh level in normal controls and in the three kinds of AD-like animal model systems. Results: Wortamannin, wortmannin and GF-109203X, and forskolin all induced AD-like hyperphosphorylation of tau and spatial memory deficits. A reduction in the levels of acetylcholine in hippocampus, compared with total creatine levels, was found in the three kinds of AD-like animal model systems. We also found that the degree of spatial memory deficits increased with the reduction of Ach in these animal models. The results agree with the concept that the decrease of ACh level is an early and leading event in AD in vivo human MRS studies. Conclusions: H MRS may be served as a sensitive and noninvasive way in vivo for the diagnosis of AD-like pathology in the early stage.