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P2–295: White matter hyperintensity load is a possible predictor of corpus callosum atrophy in the elderly: The LADIS study
Author(s) -
Ryberg Charlotte,
Rostrup Egill,
Stegmann Mikkel B.,
Barkhof Frederik,
Scheltens Philip,
Straaten Ilse,
Fazekas Franz,
Schmidt Reinhold,
Erkinjuntti Timo,
Wahlund Lars-Olof,
Basile Anna Maria,
Pantoni Leonardo,
Inzitari Domenico,
Waldemar Gunhild
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.1134
Subject(s) - corpus callosum , leukoaraiosis , splenium , white matter , hyperintensity , medicine , atrophy , dementia , brain size , anatomy , cardiology , psychology , magnetic resonance imaging , pathology , radiology , disease
tissue integrity. MT ratio (MTR) has been shown in a small number of studies to be reduced in AD. Objective: To assess whether measuring MTR in AD adds diagnostic information over and above volumetric measures. Methods: Volumetric T1-weighted images and three-dimensional MTR maps were obtained on eighteen AD patients and eighteen agematched controls. Brain and total Hc volumes were measured using semiautomated techniques and adjusted for total intracranial volume. Mean MTR was obtained for whole brain, Hc, parietal white matter (PWM) and pons. Associations of volumetric and MTR parameters with case-control status were assessed using multiple regression models. Among AD patients, volumetric and MTR parameters were each correlated with the mini-mental status examination (MMSE). Results: AD patients had significantly reduced adjusted brain volume (1019 76 vs 1125 61 ml, p 0.0001), mean brain MTR (39.8 0.7, 40.5 0.6 pu, p 0.002), adjusted total Hc volume (4.13 0.70 vs 5.64 0.51 ml, p 0.0001) and mean Hc MTR (36.7 0.8 vs 37.9 0.6 pu, p 0.0001) compared with controls. There were no significant differences between patients and controls in PWM mean MTR (44.6 1.2 vs 45.0 0.7 pu, p 0.26) and pons mean MTR (44.5 1.7 vs 44.4 1.6 pu, p 0.83). When adjusted brain volume and mean MTR were included into a multiple regression model, both were independently associated with case-control status, suggesting that measuring brain mean MTR added discriminatory value to measuring brain volumes. However, measuring mean Hc MTR added no discriminatory value over and above total Hc volume measurement. Of all MRI parameters, only adjusted brain volume was correlated with MMSE (r 0.47, p 0.048). Conclusion: This study demonstrated the independent reduction of adjusted brain volume and mean brain MTR in AD. This suggests that the two parameters reflect complementary aspects of the pathological processes in AD.