Premium
P2–278: Effects of demographic factors on cortical thickness and progression in Alzheimer's disease
Author(s) -
Seo Sang Won,
Im Kiho,
Lee Jong-Min,
Cho Yoon Sun,
Na D.L.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.1117
Subject(s) - inferior parietal lobule , posterior cingulate , atrophy , confounding , medicine , superior temporal gyrus , gyrus , audiology , cognition , radiology , psychiatry , functional magnetic resonance imaging
ease (AD) and related disorders only from their clinical aspects. To realize changes in cerebral blood flow (CBF) is helpful in distinguishing AD from other dementing disorders including dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD). This study was organized to examine diagnostic usefulness of the statistical evaluation of CBF obtained by single photon emission tomography (SPECT). Patients and Methods: Patients with probable AD by the NINCDS-ADRDA criteria (35 patients), 12 DLB patients satisfying the criteria in the third report of the DLB consortium and 12 FTD patients supported by a consensus on clinical diagnostic criteria were wellinformed and examined by 99mTc-ECD SPECT. Data were collected by Prism3000 (matrix size 128 128, Shimadzu, Japan). They were normalized, smoothed and then compared with the normal database by the eZIS program (PC software provided by Daiichi Radioisotope Labs, Japan). Finally the images were expressed as z-score of reduced CBF on 3D-MR images compared with normal age-matched groups. The data were also used for the comparison by statistical parametric mapping 99 (SPM). Cardioautonomic function was examined by measuring uptake of 123I-MIBG in DLB patients. Results: Typical z-score images in AD showed the reduction of CBF in the posterior association cortex, the posterior cingulate gyrus and the cortex around the precuneus. Typically, DLB showed hypoperfusion in the occipital cortex around the visual cortex. Prominent reduction of CBF in the frontotemporal area was consistent in FTD. All these findings were independent of brain atrophy. Comparison between AD and DLB by SPM still disclosed significant reduction of CBF in the visual cortex of DLB brain (p 0.01, uncorrected). Similarly, FTD showed significant hypoperfusion in the frontal lobe, especially in the convexity, compared with AD (p 0.01, corrected). Reduced uptake of MIBG was a consistent finding in DLB. Conclusions: Direct comparison between AD and related diseases by SPM disclosed patterns of CBF abnormalities characteristic of individual diseases. These findings should be utilized for a powerful aid of differential diagnosis. 123I-MIBG scintigraphy plays a key role to distinguish DLB from AD.