P2–243: Longitudinal changes of cerebral glucose metabolism in semantic dementia | Zendy

Diehl-Schmid Janine | Zendy; Grimmer Timo | Zendy; Drzezga Alexander | Zendy; Schwaiger Markus | Zendy; Foerstl Hans | Zendy; Kurz Alexander | Zendy

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P2–243: Longitudinal changes of cerebral glucose metabolism in semantic dementia

Author(s) -

Diehl-Schmid Janine,

Grimmer Timo,

Drzezga Alexander,

Schwaiger Markus,

Foerstl Hans,

Kurz Alexander

Publication year - 2006

Publication title -

alzheimer's and dementia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.713

H-Index - 118

eISSN - 1552-5279

pISSN - 1552-5260

DOI - 10.1016/j.jalz.2006.05.1082

Subject(s) - dementia , positron emission tomography , magnetic resonance imaging , temporal lobe , atrophy , medicine , neuropsychology , cardiology , semantic dementia , neuroimaging , nuclear medicine , functional magnetic resonance imaging , psychology , anterior cingulate cortex , cognition , neuroscience , radiology , disease , frontotemporal dementia , epilepsy

BACKGROUNDSemantic dementia (SD).OBJECTIVETo identify the pattern of decline of cerebral glucose metabolism in SD using cerebral (18)F-fluoro-2-desoxy-D-glucose positron emission tomography scanning ((18)F-FDG-PET).METHODSEight patients with SD underwent (18)F-FDG-PET at baseline and at re-examination in average 15 months later.RESULTSCompared with healthy control subjects, patients with SD showed a significant asymmetrical (left > right) hypometabolism of the temporal lobes, particularly of the anterior poles, at baseline. At follow-up, we observed a deterioration of cognitive abilities. However, in addition to the temporal lobes no other cortical or subcortical region showed a significant reduction of glucose metabolism except the anterior cingulate cortex (pcorr < 0.05).CONCLUSIONSubtle functional changes suffice to produce significant neuropsycho- logical deterioration.

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