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P2–243: Longitudinal changes of cerebral glucose metabolism in semantic dementia
Author(s) -
Diehl-Schmid Janine,
Grimmer Timo,
Drzezga Alexander,
Schwaiger Markus,
Foerstl Hans,
Kurz Alexander
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.1082
Subject(s) - dementia , positron emission tomography , magnetic resonance imaging , temporal lobe , atrophy , medicine , neuropsychology , cardiology , semantic dementia , neuroimaging , nuclear medicine , functional magnetic resonance imaging , psychology , anterior cingulate cortex , cognition , neuroscience , radiology , disease , frontotemporal dementia , epilepsy
BACKGROUNDSemantic dementia (SD).OBJECTIVETo identify the pattern of decline of cerebral glucose metabolism in SD using cerebral (18)F-fluoro-2-desoxy-D-glucose positron emission tomography scanning ((18)F-FDG-PET).METHODSEight patients with SD underwent (18)F-FDG-PET at baseline and at re-examination in average 15 months later.RESULTSCompared with healthy control subjects, patients with SD showed a significant asymmetrical (left > right) hypometabolism of the temporal lobes, particularly of the anterior poles, at baseline. At follow-up, we observed a deterioration of cognitive abilities. However, in addition to the temporal lobes no other cortical or subcortical region showed a significant reduction of glucose metabolism except the anterior cingulate cortex (pcorr < 0.05).CONCLUSIONSubtle functional changes suffice to produce significant neuropsycho- logical deterioration.