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P2–234: Cerebral blood flow velocity changes in mild cognitive impairment associated with apolipoprotein e ϵ4 allele
Author(s) -
Zhou Jiang-Ning,
Sun Zhong-Wu,
Liu Rong-Yu
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.1073
Subject(s) - medicine , cerebral blood flow , cardiology , apolipoprotein e , transcranial doppler , cerebral arteries , cognitive impairment , allele , psychology , genetics , biology , disease , gene
Background: The aim of this study was to compare resting cerebral blood flow velocity (CBFV) values of mild cognitive impairment (MCI) with those of healthy control subjects, and to explore the correlations between apolipoprotein E (apoE) E4 allele, cognitive impairment and CBFV changes in MCI. Methods: Thirty subjects with MCI and 30 controls were assessed using the Mini-Mental State Examination (MMSE) and Cambridge Cognitive Examination Chinese version (CAMCOG-C). MCI and controls were then insonated at rest in the anterior (ACA), the middle (MCA) and the basilar (BA) cerebral arteries using transcranial Doppler ultrasonography (TCD). Meanwhile, we used polymerase chain reaction (PCR) to detect the apoE genotypes of all subjects. Results: There were significant differences between MCI and controls regarding MMSE, CAMCOG-C and its subscales (memory, language, attention, praxis and orientation) (p 0.05-0.001). Compared with controls, MCI showed significant decreases in the mean (Vm), systolic (Vs) and diastolic (Vd) CBFV, bilaterally in the MCA and the ACA (p 0.05-0.001), but not in the BA (p 0.05). As the least common allele in Chinese, the E4 genotype frequencies were found in 23.33% of MCI and in 6.67% of controls, which were significantly higher in MCI than in controls (p 0.05). Compared with 17 apoE E4 non-carriers, 13 apoE E4 carriers in MCI showed significant decreases in Vm, Vs and Vd, bilaterally in the MCA (p 0.05-0.001) except for Vs of MCA-L (p 0.058). There were no significant differences of Vm, Vs and Vd in the ACA and BA (p 0.05). MMSE and CAMCOG-C scores in MCI decreased with the decline respectively in CBFVs of ACA-R (r 0.410, p 0.037) and CBFVm of MCA-L (r 0.425, p 0.030). The “memory” on CAMCOG-C correlated positively to CBFVs of MCA-R (r 0.600, p 0.001), while both the item “language” and “orientation” were associated positively with CBFVs of ACA-R (r 0.477, p 0.014; r 0.610, p 0.001; respectively). Conclusions: The decreases in CBFV in MCI, which are especially affected by apoE E4 allele, associated with cognitive impairment. If follow-up studies confirm our findings, the TCD techniques could allow an objective assessment of the perfusion state in the early phase of Alzheimer’s disease, and reliably discriminate MCI from healthy control subjects.