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P2–233: Frontal lobe MRI volumes differ in amnestic and executive subgroups of MCI
Author(s) -
Johnson Julene K.,
Chao Linda L.,
Gazzaley Adam,
Weiner Michael W.,
Kramer Joel H.,
Freeman Katie M.,
Buckley Shan,
Miller Bruce L.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.1072
Subject(s) - psychology , audiology , executive dysfunction , frontal lobe , white matter , dementia , temporal lobe , atrophy , cardiology , medicine , neuroscience , neuropsychology , cognition , magnetic resonance imaging , radiology , epilepsy , disease
follow-up the proportion of non-decliners was significantly higher in the GDS1 than GDS2 group (69% vs. 37%, chi 8.4), p .05). Based on the severity of complaint, age and severity of depressive symptoms, discriminant function analyses successfully predicted 84.6% of the unstable, 63.6% of declining and 49% of the non-declining group. Overall 60.3% of the original group was correctly classified. Membership in the declining group was poorly predicted by the severity of SMCs. However, the unstable group at follow-up was associated with younger age, more depressive symptoms, and more severe SMCs at baseline. Conclusions: The lack of SMCs is associated with a good outcome, but once there are subjective complaints, a greater severity does not indicate greater risk of decline. Rather, more severe SMCs are characteristic for the diagnostically unstable group. Together with higher depressive symptoms and younger age, severe SMCs may designate a subgroup that should be observed with caution to avoid possible misdiagnoses.