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P2–224: Regional overlap of cerebral glucose metabolism at rest and during list learning for older insulin resistant and Alzheimer adults
Author(s) -
Baker Laura D.,
Minoshima Satoshi,
Cross Donna,
Belongia Dana,
Watson G. Stennis,
Craft Suzanne
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.1063
Subject(s) - insulin resistance , hyperinsulinemia , insulin , medicine , cognition , diabetes mellitus , type 2 diabetes , neuroimaging , cognitive decline , positron emission tomography , peripheral , endocrinology , disease , dementia , nuclear medicine , psychiatry
total tau, and p-tau 181 levels in CSF. Objective: To investigate predictors of a 1-year outcome. Subjects: Inclusion criteria were age 55 years and a new referral to a memory clinic. Exclusion criteria were dementia and disorders causing cognitive impairment. For the present analysis we selected all subjects with data on the 1-year follow-up (n 298). Subjects were at baseline on average 71 years old, scored 27.5 on the MMSE, and had 9.5 years of education. 59% of the subjects were female. Data on the APOE genotype, medial temporal lobe atrophy, and CSF values were collected in a subgroup only. Outcome measures were AD and cognitive decline at follow-up. Cognitive decline was defined as AD at follow-up, decline of at least 1 standard deviation on a memory test, or persisting memory impairment. Results: Predictors of AD were score on the delayed recall of a word list (t 2.6, p 0.01), verbal fluency (t 2.5, p 0.01), MMSE score (t 3.3, p 0.003), total tau (t 4.0, p 0.003), and p-tau 181 (t 2.5, p 0.02). Predictors of cognitive decline were age (t 4.0, p 0.001), score on the delayed recall of a word list (t 10, p 0.001), verbal fluency (t 7.9, p 0.001), score on the TMT B (t 3.1, p 0.002), MMSE score (t 5.2, p 0.001), functional impairment (chi-square 9.2, p 0.01), medial temporal lobe atrophy (chi-square 23, p 0.001), total tau (t 2.3, p 0.04), and the APOE-e4 allele (chi-square 4.4, p 0.04). Conclusions: Subjects who rapidly decline to AD are characterized by low cognitive scores and high CSF tau levels at baseline. Other predictors of AD such as age, functional impairment, medial temporal lobe atrophy, and the APOE-e4 allele may predict AD only at longer follow-up intervals. Acknowledgement: The study was funded by the European Commission (QLRT-2001-2455).