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P2–218: Multidomain MCI amnestic is the prevailing diagnosis among cognitively impaired nonagenarians and centenarians
Author(s) -
Pioggiosi Philippe P.,
Ujkaj Manjola,
Atti Anna Rita,
Caprini Sara,
De Ronchi Diana
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.1057
Subject(s) - cognitive impairment , psychology , homogeneous , cohort , memory impairment , gerontology , elderly people , audiology , cognition , medicine , psychiatry , thermodynamics , physics
selected for MRS imaging: left temporal pole (LTP), posterior left temporal (PLT) and posterior cingulate (PC). Results: Prd AD showed significantly lower memory performance than MCI, without significant language, praxis, visuospatial or frontal deterioration. Mioinoisitol (MI)/Cr (Creatine) and Choline (Cho)/Cr ratios in the PC were significantly increased (p 0.005) both in the MCI and Prd AD groups respective to the control group. Absolute N-Acetylaspartate (NAA) measure in the PC resulted significantly decreased (p 0.005) in the Prd AD respective to MCI, and Glutamate/Cr ratio in the LTP was significantly increased in the Prd AD compared with AD (p 0.005). 16 MCI patients and 7 Prd AD patients were follow-up during one year. The conversion rate for Prd AD was 60 % and for MCI was 20%. Conclusion: Patients fulfilling criteria for Prd AD present distinct neuropsychological and MRS profile from MCI and AD, with a higher conversion rate than MCI.