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P2–199: Grey matter loss in amnestic MCI according to the profile of memory impairment
Author(s) -
Ceccaldi Mathieu,
Barbeau Emmanuel,
Ranjeva Jean-Philiphe,
Didic Mira,
Confort-Gouny Sylviane,
Felician Olivier,
Cozzone Patrick J.,
Poncet Michel
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.1037
Subject(s) - atrophy , grey matter , psychology , recall , audiology , memory impairment , voxel based morphometry , voxel , episodic memory , visual memory , neuroscience , magnetic resonance imaging , medicine , pathology , cognitive psychology , white matter , cognition , radiology
their 50s to 70s. The pattern of glucose metabolic changes in older MCI patients has not been established. Objective: To determine the effect of age on the regional pattern of glucose uptake in patients with MCI, who were stratified to older and younger groups. Methods: Ten patients with MCI with a mean (range) age of 67 (55-72) and 10 patients with MCI with a mean (range) age of 79 (74-86), along with 22 age and gender matched controls and 11 AD patients underwent clinical evaluation, FDG PET and MRI. The disease duration of MCI was similar in the two MCI groups. We compared the glucose uptake (scaled to pontine uptake) in the younger and older MCI patients and AD patients with their age and gender matched control groups separately using both statistical parametric mapping and atlas-based analysis of regional glucose uptake. Results: Statistical parametric mapping showed that younger MCI patients had reduced glucose uptake in the posterior cingulate gyri and in the right prefrontal cortex. Older MCI patients had reduced glucose uptake in the right and left prefrontal cortices. Patients with AD had reduced glucose uptake in the parietal and temporal cortices (Figure, p 0.001 uncorrected for multiple comparisons). Atlas-based regional analysis was in agreement with statistical parametric mapping. Conclusion: Patients with MCI who are younger than 73 years of age have reduced glucose metabolism in the posterior cingulate gyri, in agreement with previous observations in this age group. However, regional patterns of glucose metabolism reduction differed in older patients with MCI, limiting the generalizability of previously reported metabolism patterns in MCI. Possibly a higher rate of incipient AD in the older control group used for reference, and a higher rate of comorbidities in the older MCI group may be the reasons for observing a different pattern of change in glucose metabolism in older MCI patients.