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P2–196: Whether depressive symptoms/syndromes are predictors of progression in mild cognitive impairment?
Author(s) -
Gabryelewicz Tomasz,
Barczak Anna,
Luczywek Elzbieta,
Wasiak Boguslaw,
Styczynska Maria,
Pfeffer Anna,
Chodakowska Malgorzata,
Czyzewski Krzysztof,
Barcikowska Maria
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.1034
Subject(s) - depression (economics) , dementia , cognition , medicine , psychology , sadness , clinical dementia rating , depressive symptoms , disease , clinical psychology , psychiatry , anger , economics , macroeconomics
(MCI) have been proposed, the predictive validity of them has not been examined. Objective(s): We aimed to examine the validity from a longitudinal community-based study in Japan. Methods: After obtaining informed consent, a community sample of 1490 dementia-free individuals aged 65 and older was followed using neurolopsychological tests covering 5 domains of cognition (memory, attention, language, visuo-spatial, and reasoning) for 3 years. According to the method of Busse et al.(cut-off point of severity level:1.0, 1.5, 2.0 SD, presence or absence of subjective cognitive decline), we defined 18 types of modified MCI definition originating from three types of MCI (MCI-amnestic, MCI-multiple domains slightly impaired, MCI-single non-memory domain) on the basis of the examination results at the baseline. We standardized the results of the tests taking age, sex, and years of education into consideration. Three years later, 1023 of the original dementia-free participants underwent the second examination using the results of the same tests as the baseline, and we made a diagnosis of normal, MCI, and dementia for each participant. Results: The incidence of dementia during the observation period was 3.8% (1.3%/year). The convert rates from MCI to dementia showed a wide range difference depending on the subset of MCI employed. All six types of MCI-amnestic showed higher diagnostic specificity (more than 96%) but lower sensitivity (10% and less) in general. The use of modified criteria of MCI-multiple domains slightly impaired (original criteria except for the report of subjective cognitive decline and 1.0 SD cut-off level) showed relatively higher sensitivity (31%) but lower specificity (82%) and positive predictive power (7.4%). Conclusions: We should know the difference in sensitivity and specificity according to the subset of MCI. The convert rate from MCI to dementia appears to be different between community-based and clinic-based studies.