Premium
P2–193: Progression of cognitive impairments in mild cognitive impairment: What is the next domain to be impaired after memory?
Author(s) -
Negash Selam,
Geda Yonas E.,
Pankratz V. Shane,
Knopman David S.,
Boeve Bradley F.,
Smith Glenn E.,
Ivnik Robert J.,
Slusser Tiffani C.,
Petersen Ronald C.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.1031
Subject(s) - proportional hazards model , cognition , psychology , audiology , hazard ratio , working memory , hazard , confidence interval , medicine , psychiatry , chemistry , organic chemistry
general cognitive functions, normal activities of daily living, and absence of pathology associated with dementia or memory disorders. Converging evidence suggests that episodic memory deficits are most pronounced in amnestic MCI, yet it is unclear what aspects of episodic memory are affected and how the pattern of impairment may differ from mild AD. Objective: This study compared aspects of episodic memory including learning rate, immediate, delayed, and cued recall, and retention rate in a sample of amnestic MCI, mild AD, and healthy older individuals. Methods: Episodic memory profiles from neuropsychological evaluations were examined for 22 AD (mean MMSE 23.77, SD 2.87), 23 amnestic MCI (mean MMSE 27.52, SD 2.25), and 21 healthy adults (mean MMSE 28.57, SD 1.25). The groups were equated for age, education, and vocabulary level. The memory battery included a visual memory test (Visual Reproduction subtest from the Wechsler Memory Scale-III) and verbal memory tests assessing prose (Logical Memory Scale from the WMS-III), and word list (California Verbal Learning Test-II) learning and recall. Results: In general, episodic memory for prose, word lists, and visual reproduction was impaired for MCI compared to healthy adults, but was higher than for AD individuals. Although the learning rate for MCI and healthy adults was comparable, MCI individuals retained less, recalled less verbal and visual information, gained less from semantic cueing, and had a higher number of intrusions during recall than did healthy adults. In comparison to AD individuals, MCI adults displayed a higher learning rate, greater retention for visual information, more benefit from semantic cueing, and higher recall for verbal and visual material. MCI and AD individuals did not differ significantly either in retention rate for verbal material or susceptibility to interference during verbal recall. Conclusions: The memory profile for amnestic MCI individuals suggests general impairment compared to healthy adults across most aspects of episodic memory including immediate, delayed and cued recall and susceptibility to interference, with deficits in retention rate for verbal memory comparable to mild AD.