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P2–187: Comparison between the standard Mini Mental State Examination and the modified version (3MS) in healthy subjects and patients with mild cognitive impairment or dementia. Mérida–Venezuela, 2005–2006
Author(s) -
Ramirez Clara I.,
Baptista Trino J.,
Serrano Ana,
Arape Yinet,
Tho Evelyn
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.1025
Subject(s) - dementia , cognitive impairment , medicine , mental state , cognition , psychiatry , neurology , mini–mental state examination , gerontology , psychology , clinical psychology , disease
both clinical conversion status as well as APOE genotype. These results validate the technical feasibility of using MRI as an outcome measure of disease progression in multi-center trials for amnestic MCI. Failure to detect a significant treatment effect in the MRI data could reflect the absence of a biologic effect of either vitamin E or donepezil on brain volume itself. Or it could simply represent inadequate sample size in the treatment groups: donepezil (n 36 40, number varies with different MRI measures), vitamin E (n 34 -43).