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S2–02–05: Neuritic alterations and dysfunctions in Alzheimer's disease
Author(s) -
Hyman Bradley T.,
Spires Tara,
Matsui Toshifumi,
Orne Jen,
Pitstik Rose,
Carlson George A.,
Ashe Karen
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.05.085
Subject(s) - tauopathy , neuroscience , tau protein , neurofibrillary tangle , biology , senile plaques , genetically modified mouse , neurite , neurodegeneration , transgene , alzheimer's disease , neuron , programmed cell death , caspase , tangle , pathology , microbiology and biotechnology , apoptosis , medicine , disease , in vitro , genetics , gene , mathematics , pure mathematics
not available. S2-03-06 FUNCTIONAL AND STRUCTURAL ANALYSIS OF -SECRETASE Harald Steiner, Edith Winkler, Aya Yamasaki, Keiro Shirotani, Blanca Perez Revuelta, Masanori Tomioka, Christian Haass, LudwigMaximilians-University, Adolf-Butenandt-Institute, Munich, Germany. Contact e-mail: hsteiner@med.uni-muenchen.de Background: -Secretase catalyzes the intramembrane cleavage of a large variety of type I membrane proteins including the Alzheimer s disease -amyloid precursor protein. Biochemical and genetic studies demonstrated that -secretase is a complex composed of presenilin (PS), nicastrin (NCT), APH-1 and PEN-2. In human cells, two PS homologues, PS1 and PS2, and two APH-1 homologues, APH-1a and APH-1b, were identified and shown to be part of distinct -secretase complexes demonstrating that -secretase represents a heterogeneous activity. Apart from the established role of PS as the catalytic subunit of -secretase and the recently proposed role of NCT as substrate receptor, knowledge about the function of the other subunits within the complex, in particular regarding the mechanism S27 Symposia S2-03: Disease Mechanisms (Presenilins/ -Secretase)