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Commentary on “Vascular cognitive impairment: Today and tomorrow”
Author(s) -
Markesbery William R.
Publication year - 2006
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2006.04.004
Subject(s) - cognitive impairment , citation , library science , computer science , cognitive science , cognition , psychology , neuroscience
Progress has been slow in our understanding of cognitive impairment related to vascular brain injury. The uncertainties surrounding this disorder are demonstrated by the different names applied to it over the last 50 years: atherosclerotic dementia, multi-infarct dementia, vascular dementia, and now vascular cognitive impairment (VCI). There is considerable disagreement about the frequency of this entity, how it is diagnosed clinically, its pathology, and its overlap with other dementing disorders, especially Alzheimer’s disease (AD). Animal models of this disorder have not been developed. Multiple views, reviews, and books about this topic have been published, but they contain little agreement about many facets of this disorder. In this issue, Dr. Chui, calling on her years of experience and knowledge as an investigator of this entity, has written a thorough, scholarly update of VCI with emphasis on longitudinal epidemiologic studies with and without autopsies [1]. The review leads to a number of logical conclusions, which put the disorder in a clearer perspective.