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[O1‐02‐08]: Assessment of complex ADL is essential for the diagnosis of the MCI syndrome
Author(s) -
Perneczky Robert
Publication year - 2005
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2005.06.291
Subject(s) - activities of daily living , dementia , cognition , clinical dementia rating , cognitive impairment , medicine , memory clinic , disease , logistic regression , psychology , physical medicine and rehabilitation , physical therapy , gerontology , psychiatry
prevention or treatment of sporadic AD in the general One obstacle to conducting trials with DS participants in the paucity of data on outcome measures to assess treatment efficacy. This report describes a multinational cohort of individuals with DS enrolled in a clinical trial. Objectives: To describe, clinical features of the study cohort, newly developed outcome measures, and to evaluate performance of these measures in cross-sectional analyses of elderly ( 50 yrs) individuals with DS enrolled in the trial. Methods: The primary outcome measure is the Brief Praxis Test (BPT), a non-verbal, 20-item version of a longer praxis scale for adults with DS. A series of secondary outcome measures were adapted. Results: The mean age of enrolled subjects was 54.7; approximately 70% were not demented and 30% had a diagnosis of probable AD. The level of intellectual disability was mild (IQ: 50-69) for 24% of the cohort, moderate (IQ:35-49) for 51% of the cohort and severe or profound for the rest. The majority (83%) live in a residential facility. The primary outcome measure had excellent test-retest reliability ( r .805 ) and sensitive to a diagnosis of dementia, (dementia: 58.9 15.49 vs. no dementia: 65.2 12.14. F(1, 103) 4.95, p .03). Verbal memory was associated with dementia ((mean score: dementia 8.6 vs. no dementia 19.7; F 18.453; P 0.0001) as was delayed recall (F 1.494; P 0.007). Visual memory and orientation proved too difficult for some members of the cohort. Vocabulary was sensitive to both premorbid intellectual disability and the presence of dementia. The Clinical Global Impression of Change ratings were not correlated with age, gender or MR level, but were associated with dementia status. Conclusions: It appears that appropriate primary and secondary measures to assess cognitive therapies in DS have been identified, providing the first step to assessing disease altering drugs.