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[P‐217]: Compliance with neuropsychological testing may lead to underestimation of decline in Cognitively‐Impaired‐Not‐Demented (CIND) individuals
Author(s) -
Jacova Claudia,
Hsiung Ging-Yuek R.,
Peters Kevin R.,
Feldman Howard H.
Publication year - 2005
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2005.06.275
Subject(s) - dementia , cohort , neuropsychology , clinical dementia rating , generalizability theory , medicine , neuropsychological test , psychology , etiology , clinical psychology , cognition , psychiatry , disease , developmental psychology
subjects aged 65 or older. In the present study subjects all were clinically evaluated at entry and at 5 years. The diagnoses of normal, CIND and dementia were made according to DSM-III-R criteria. Rates of progression were computed for IN and CO subjects and then stratified by age group ( 75 or 75), sex, education ( grade 12, grade 12) and initial Modified Mini-Mental Status Examination (3MS) ( 90 or 90). Chi-square tests were performed with significant findings based on p 0.05. Results: There were 322 subjects (63 IN, 259 CO) at baseline who were diagnosed as cognitively normal. Of these 66% remained normal after 5 years, 23% progressed to CIND and 11% to dementia. Compared to CO subjects, IN subjects had significantly higher rates of progression to CIND (27 vs. 22%) and to dementia (18 vs. 9%). For age and 3MS level, this effect was specific to age 75 years and 3MS 90. Conclusion: Elderly individuals living in institutions are identified to be at an increased risk of developing both cognitive impairment and dementia. This environmental factor may further assist the enrichment of RCT study samples and should raise awareness of the potential role of non-biological factors within prevention study designs.