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[P‐125]: Influence of age, grey matter, and memory performance on fMRI activation in older adults
Author(s) -
Braskie Meredith N.,
Small Gary W.,
Bookheimer Susan Y.
Publication year - 2005
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2005.06.198
Subject(s) - psychology , posterior cingulate , audiology , grey matter , working memory , neuroimaging , functional magnetic resonance imaging , cognition , neuroscience , magnetic resonance imaging , medicine , white matter , radiology
inferior frontal gyrus (p .002) and bilateral frontopolar regions (p’s .001). For delayed cued recall, correlations were identified in left superior frontal gyrus (p .01), right superior frontal gyrus (p .001) and right superior parietal cortex (p .001). No significant correlations were identified for delayed free recall or delayed recognition. Conclusion: These results suggest that in MCI, cognitive impairments are associated with reduced cerebral perfusion. Furthermore, since we corrected for partial volume effects, correlations between perfusion and cognition cannot be explained by brain tissue loss alone. Memory impairments in MCI may be those most influenced by executive functioning, as evidenced by the greatest deficits in immediate and delayed cued recall. Furthermore, the results from the correlations highlight the importance of multiple frontal regions as well as posterior association areas, typically implicated in MCI, in potentially substantiating these cognitive impairments. In conclusion, these results suggest that perfusion MRI can be used to stage cognitive deficits in MCI.