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[P‐107]: Quantifying T1‐rho in Alzheimer's disease
Author(s) -
Borthakur Ari,
Moonis Gul,
Wheaton Andrew J.,
Melhem Elias R.,
Clark Christopher,
Reddy Ravinder
Publication year - 2005
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2005.06.181
Subject(s) - nuclear magnetic resonance , nuclear medicine , pulse (music) , magnetic resonance imaging , spin–spin relaxation , spin echo , scanner , spin–lattice relaxation , relaxation (psychology) , pulse sequence , medicine , biomedical engineering , materials science , physics , radiology , optics , detector , nuclear quadrupole resonance
clearance t1/2 and distribution volume ratios (DVR) were calculated through graphical analysis using the cerebellum as reference region. PIB parameters were compared with FDG uptake. Images showed marked binding in all AD subjects, especially in frontal, parietal and lateral temporal cortices as well as in the caudate nuclei with relative sparing of occipital and sensorimotor cortex, and very low uptake in cerebellar cortex. Images in LBD subjects were similar to AD subjects, though slightly higher uptake was observed in occipital and sensorimotor cortex. Cortical PIB clearance was significantly slower in LBD (t1/2 109 /28 min) and AD patients (t1/2 92 /13 min) when compared with control subjects (t1/2 61 /9 min). Clearance from cerebellar cortex was the same in all groups. Significantly higher DVR in neocortical areas were observed in AD (1.99 /0.36, p 0.01) and LBD patients (1.81 /0.25, p 0.01) when compared with control subjects (1.25 /0.23). There was an inverse correlation between PIB binding and glucose metabolism (r -0.67, p 0.0001). Regional uptake asymmetry indices were greater in LBD both in PIB and FDG studies. Conclusion: C-PIB PET suggests that cortical A is present in LBD subjects with progressive dementia in a similar degree to AD subjects. Longitudinal studies are warranted to more clearly define the role of A deposition in the development of dementia in both AD and LBD.