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[P‐060]: The effect of social engagement on incident dementia and hippocampal volume: The Honolulu‐Asia aging study
Author(s) -
Saczynski Jane S.,
Pfeifer Lisa A.,
Masaki Kamal,
Korf Esther S.C.,
Laurin Danielle,
White Lon,
Launer Lenore J.
Publication year - 2005
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2005.06.134
Subject(s) - dementia , psychology , gerontology , marital status , social engagement , cognition , social support , demography , medicine , psychiatry , social psychology , disease , environmental health , population , social science , sociology
2.91 (95% CI 1.10-7.71, p 0.03), the effect was strongest in those under the age of 75 years with a RR of 3.37 (95% CI 1.30-8.73, p 0.01). Whereas DM did not increase the risk of incident AD in the Framingham cohort overall, it emerged as a potentially important risk factor in individuals without the APOE 4 allele or elevated tHcy. Our data suggest that the impact of DM on AD risk may be more evident in the absence of other major risk factors.