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[S1‐02‐02]: CSF biomarkers
Author(s) -
Zetterberg Henrik,
Blennow Kaj
Publication year - 2005
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2005.06.060
Subject(s) - biomarker , medicine , context (archaeology) , disease , cerebrospinal fluid , tau protein , diagnostic biomarker , gene isoform , pathology , alzheimer's disease , diagnostic accuracy , biology , biochemistry , paleontology , gene
Background: MRI continues to have a large impact. The past five years have seen new developments in MRI technology that are leading to significantly higher resolution. In addition, new molecular imaging agents are being tested in animal models that will increase the range of information available from MRI. Objectives: The goal of this talk is to illustrate recent developments of MRI that demonstrate the potential impact of increased resolution and the potential of two imaging agents. Results of MRI of mouse models of neurological disorders are clearly demonstrating the benefits of very high resolution analysis of the brain. The potential for increasing resolution in the human brain for measurements of both anatomy and regional blood flow will be illustrated. Work with two agents that are increasing information from MRI in animal models will be reviewed. Manganese Enhanced MRI is leading to contrast that can report on neural activity, neural connectivity, as well as give novel anatomical contrast. Iron oxide based contrast is enabling MRI detection of migration of cells in vivo, with the potential to detect single cells. Methods: MRI of rodent brain was obtained on a 11.7T, 31 cm magnet (Magnex, UK) interfaced to an Avance imaging console (Bruker Inc, MA), with specially designed gradients and shims (Resonance Research, MA). MRI of the human brain was obtained on 3T and 7T MRI (General Electric, WI) utilizing specially designed multi-channel detectors (Nova Biomedical, MA). Conclusions: Developments in MRI is leading to increases in sensitivity of almost ten fold thanks to new array detectors and higher magnetic fields. This is leading to increases in resolution for all MRI techniques in human and animal brain. The rapid growth in interest in molecular imaging is leading to new agents that will greatly expand the information from MRI. All of these developments are occurring in animal models or on specialized equipment. While there are many hurdles to be overcome before they can be applied routinely to study diseases of the human brain, it is clear that the range of information from MRI will continue to grow rapidly.